Jason X-J Yuan Selected Research

Familial Primary Pulmonary Hypertension

12/2021	Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
1/2021	Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.
7/2020	Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension.
1/2020	MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.
1/2020	Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis.
1/2017	Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.
12/2013	Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension.
2/2013	Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells.
1/2013	[Enhanced Ca2+-sensing receptor function in pulmonary hypertension].
7/2009	Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.

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Jason X-J Yuan Research Topics

Disease

49	Pulmonary Hypertension 01/2022 - 02/2003
38	Hypoxia (Hypoxemia) 11/2022 - 12/2003
23	Pulmonary Arterial Hypertension 01/2022 - 09/2002
22	Vascular Remodeling 01/2022 - 09/2002
16	Familial Primary Pulmonary Hypertension 12/2021 - 09/2004
6	Right Ventricular Hypertrophy 12/2018 - 10/2010
5	Vascular Diseases (Vascular Disease) 01/2022 - 01/2011
4	Fibrosis (Cirrhosis) 01/2021 - 05/2011
4	Lung Injury 01/2021 - 10/2011
4	Neoplasms (Cancer) 01/2019 - 08/2011
4	Hypertrophy 01/2016 - 12/2005
3	Lung Diseases (Lung Disease) 11/2022 - 08/2013
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2022 - 01/2017
3	Type 2 Diabetes Mellitus (MODY) 11/2021 - 01/2020
3	COVID-19 12/2020 - 01/2020
3	Hypertension (High Blood Pressure) 01/2014 - 12/2008
2	Wounds and Injuries (Trauma) 05/2022 - 04/2006
2	Cardiomyopathies (Cardiomyopathy) 01/2021 - 02/2011
2	Ventilator-Induced Lung Injury 01/2021 - 01/2017
2	Respiratory Insufficiency (Respiratory Failure) 01/2021 - 01/2017
2	Critical Illness (Critically Ill) 01/2021 - 01/2017
2	Starvation 01/2021 - 12/2013
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 08/2013
2	Acute Lung Injury 01/2017 - 10/2011
2	Inflammation (Inflammations) 02/2013 - 06/2009
2	Lewy Body Disease (Lewy Body Dementia) 09/2008 - 04/2007
2	Cystic Fibrosis (Mucoviscidosis) 08/2007 - 01/2005
1	Hyperplasia 11/2022
1	Respiratory Tract Diseases (Respiratory Tract Disease) 12/2021

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2003
11	MonocrotalineIBA 01/2021 - 10/2010
9	Ion Channels (Ion Channel)IBA 01/2021 - 09/2002
8	Messenger RNA (mRNA)IBA 01/2018 - 02/2003
6	Pharmaceutical PreparationsIBA 12/2021 - 01/2017
5	MicroRNAs (MicroRNA)IBA 01/2020 - 09/2013
5	Protein Isoforms (Isoforms)IBA 01/2015 - 01/2007
4	Therapeutic UsesIBA 01/2022 - 01/2017
4	Semaxinib (SU5416)IBA 01/2022 - 01/2019
4	CationsIBA 01/2022 - 01/2011
4	LigandsIBA 01/2022 - 05/2014
4	TRPC6 Cation ChannelIBA 12/2021 - 05/2009
4	Platelet-Derived Growth FactorIBA 07/2020 - 01/2012
4	Transient Receptor Potential ChannelsIBA 01/2019 - 09/2004
3	CalciumIBA 01/2021 - 01/2016
3	Angiotensin-Converting Enzyme 2IBA 12/2020 - 01/2020
3	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 07/2020 - 10/2008
3	CollagenIBA 01/2020 - 05/2011
3	Calcium-Sensing ReceptorsIBA 01/2020 - 01/2013
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 04/2010
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 10/2011
3	Oxygen (Dioxygen)IBA 01/2020 - 10/2007
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2017 - 06/2012
3	N- (2- hydroxy- 3- (2- cyano- 3- chlorophenoxy)propyl)- 1,1- dimethyl- 2- (2- nephthyl)ethylamineIBA 02/2014 - 08/2012
3	Calcium Channels (Calcium Channel)IBA 07/2013 - 01/2012
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 01/2016
2	CytokinesIBA 01/2022 - 06/2009
2	Biological ProductsIBA 12/2021 - 12/2003
2	Thymidine Monophosphate (TMP)IBA 03/2021 - 01/2020
2	tetramethylpyrazineIBA 03/2021 - 01/2020
2	PotassiumIBA 01/2021 - 01/2005
2	Sirolimus (Rapamycin)FDA Link 01/2021 - 10/2009
2	Conditioned Culture MediaIBA 07/2020 - 12/2005
2	Chloroquine (Aralen)FDA LinkGeneric 01/2020 - 11/2017
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2020 - 12/2016
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2020 - 12/2018
2	Stromal Interaction Molecule 2IBA 01/2020 - 01/2018
2	Nicotinamide PhosphoribosyltransferaseIBA 01/2020 - 01/2017
2	Phosphotransferases (Kinase)IBA 01/2019 - 04/2014
2	TOR Serine-Threonine KinasesIBA 12/2018 - 01/2015
2	EnzymesIBA 01/2018 - 01/2014
2	Ether (Diethyl Ether)IBA 03/2016 - 01/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2015 - 10/2007
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 09/2015 - 11/2009
2	Thrombin FDA Link 12/2013 - 12/2008
2	Angiopoietin-1IBA 10/2011 - 02/2003
2	Atrial Natriuretic Factor (ANF)IBA 05/2011 - 12/2005
2	Sildenafil Citrate (Viagra)FDA Link 01/2011 - 10/2010
2	Simvastatin (Zocor)FDA LinkGeneric 01/2011 - 10/2010
2	Caveolin 1IBA 07/2009 - 09/2007
2	alpha-SynucleinIBA 09/2008 - 04/2007
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 08/2007 - 01/2005
2	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 08/2007 - 01/2005
2	Cyclic NucleotidesIBA 05/2007 - 01/2007
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2006 - 02/2003
1	Calcitonin Gene-Related Peptide Receptor AntagonistsIBA 11/2022
1	Calcitonin Gene-Related PeptideIBA 11/2022
1	NeuropeptidesIBA 11/2022
1	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)IBA 11/2022
1	Nicotine FDA Link 05/2022
1	TropomodulinIBA 01/2022
1	PT2385IBA 01/2022
1	hydroxide ionIBA 01/2022
1	AntigensIBA 11/2021
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2021
1	Silicone Elastomers (SE 30)IBA 10/2021
1	PolymersIBA 10/2021
1	AerosolsIBA 03/2021
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 01/2021

Therapy/Procedure

9	Therapeutics 01/2022 - 04/2006
2	Artificial Respiration (Mechanical Ventilation) 01/2021 - 01/2017